CCR8 monoclonal antibody
T Regulatory Cells (Tregs)
- Normal function of these cells is to prevent immune attack of our own tissues
- Tumor cells attract and “highjack” Tregs to use them to prevent immune attack
CCR8 chemokine receptor has a specific expression profile on regulatory T cells found in the tumor micro-environment and CCR8+ regulatory T cells (Treg cells) have been identified as drivers of immunosuppression. iTeos initiated a drug discovery program to identify specific ADCC-enabled antibody.